Ceramide-Mediated Insulin Resistance and Impairment of Cognitive-Motor Functions
نویسندگان
چکیده
منابع مشابه
Mechanistic interplay between ceramide and insulin resistance
Recent research adds to a growing body of literature on the essential role of ceramides in glucose homeostasis and insulin signaling, while the mechanistic interplay between various components of ceramide metabolism remains to be quantified. We present an extended model of C16:0 ceramide production through both the de novo synthesis and the salvage pathways. We verify our model with a combinati...
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Insulin resistance is a key feature of type 2 diabetes, and the strong association between fat oversupply and defective insulin action in target tissues, especially skeletal muscle and liver, has motivated the search for intracellular lipid mediators that can interfere with insulin signaling and glucose homeostasis. Two of the best-studied candidates are diacylglycerol (DAG) and ceramide (1–3),...
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ژورنال
عنوان ژورنال: Journal of Alzheimer's Disease
سال: 2010
ISSN: 1875-8908,1387-2877
DOI: 10.3233/jad-2010-091726